General Information

  • ID:  hor004426
  • Uniprot ID:  P86585
  • Protein name:  Tachykinin-related peptide 4
  • Gene name:  NA
  • Organism:  Oncopeltus fasciatus (Large milkweed bug)
  • Family:  Tachykinin family
  • Source:  Animal
  • Expression:  Expressed in the abdominal ventral nerve cord (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncopeltus (genus), Lygaeinae (subfamily), Lygaeidae (family), Lygaeoidea (superfamily), Pentatomomorpha (infraorder), Panheteroptera, Neoheteroptera, Euheteroptera, Heteroptera (suborder), Prosorrhyncha, Hemiptera (order), Paraneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NPASGFFGMR
  • Length:  10(1-10)
  • Propeptide:  NPASGFFGMR
  • Signal peptide:  NA
  • Modification:  T10 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004426_AF2.pdbhor004426_ESM.pdb

Physical Information

Mass: 124393 Formula: C48H70N14O13S
Absent amino acids: CDEHIKLQTVWY Common amino acids: FG
pI: 10.55 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -19 Boman Index: -1296
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 10
Instability Index: 1784 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19084564
  • Title:  Neuropeptides in Heteroptera: Identification of Allatotropin-Related Peptide and Tachykinin-Related Peptides Using MALDI-TOF Mass Spectrometry